Biochemistry

Archives

Nicole Martinez

Eukaryotic messenger RNAs (mRNAs) are extensively chemically modified to create non-canonical bases that can impact their fate and function in cells. The full collection of RNA modifications in cellular mRNAs, the epitranscriptome, represents a previously... Continue Reading

Amy Weeks

Post-translational modifications (PTMs) control the structure, activity, localization, and lifetime of nearly all proteins and are often dysregulated in human disease. Identification of PTMs has far outpaced assignment of their biological functions, an endeavor that... Continue Reading

Scott Coyle

My lab is taking a reverse-engineering approach to understand how cells move through, interact with and respond to their environment to perform complex and essential behaviors. We treat behavior as the output of a microscopic... Continue Reading

Bowman, Gregory R.

A protein is a dynamic shape-shifter whose function is determined by the set of different structures it adopts. Unfortunately, it is impossible to directly observe most of these structures. Our lab combines computer simulations and... Continue Reading

Petry, Sabine

I research how the cytoskeleton gives cells their shape, positions organelles, moves materials, and divides cells. I use biochemical and engineering approaches to uncover the mechanisms that generate its architecture. My research reveals how cellular... Continue Reading

Fraser, James S.

The long-term goals in our research group are to understand how protein conformational ensembles are reshaped by perturbations and to quantify how these perturbations impact protein function and organismal fitness. To accomplish these goals, our... Continue Reading

Nam, Yunsun

Our lab studies mechanisms underlying gene regulation by non-protein-coding RNAs (ncRNAs). Many RNAs are transcribed but have functions other than to translate the sequence information to proteins. To fulfill a specific role, each RNA has... Continue Reading

Yu, Hongtao

My laboratory’s long-term research interest is to elucidate cellular mechanisms that govern chromosome inheritance and integrity, with a combination of cell biological, biochemical, and biophysical methods. In particular, our research program aims to understand the... Continue Reading

Weissman, Jonathan S.

I am looking at how cells ensure that proteins fold into their correct shape, as well as the role of protein misfolding in disease and normal physiology. I am also developing experimental and analytical approaches... Continue Reading

Wolberger, Cynthia

Current research in my laboratory is focused on the fundamental mechanisms of ubiquitin signaling and regulation of mRNA transcription, with a focus on the role of histone ubiquitination in regulating transcription and chromatin dynamics. My... Continue Reading