About Annabelle C. Singer's Work
Singer’s research has shown how coordinated electrical activity across many neurons in the hippocampus represents memories of experiences. She has found that this activity fails in animal models of Alzheimer’s disease and engineering neurons to produce this activity has neuroprotective effects. Her long-term goal is to understand how neural activity both produces memories and protects brain health, while using this knowledge to engineer neural activity to treat brain diseases. Integrating innovative experimental and analytical methods, her research will provide unprecedented insight into how neural activity failures lead to memory impairment and will reveal novel ways to engineer neural activity to repair brain function. Using non-invasive approaches, she will translate these discoveries from rodents to humans. These insights could lead to radically new ways to treat diseases that affect memory like Alzheimer’s, for which there are no effective therapies.