My laboratory studies the evolution of antibiotic resistance, with the ultimate aim of enabling therapies to forestall or prevent resistance evolution. We aim to ‘play a move ahead’ of antibiotic resistance and discover therapies and control strategies informed by the predictability of microbial evolution. Our research is divided into three cross-informative efforts: 1) Understanding the science of resistance evolution, in particular to predict evolutionary options available to the pathogen. 2) Developing technology to diagnose resistance rapidly at the point of care, and 3) Discovering treatment strategies to manipulate the evolution of resistance. Through this research we hope to understand the fascinating process of microbial evolution and to enable new strategies to counter the emerging global threat of antibiotic resistance.