Arthur D. Lander

1988 Fellow

Fellowship Institution: Massachusetts Institute of Technology

Current Institution: University of California, Irvine

Biological Sciences

Visit Lab Website

Connect with Arthur D. Lander:

About Arthur D. Lander's Work

My lab is interested in biological control, with “control” meant in its engineering sense: execution of strategies for achieving useful ends, such as precision, robustness, efficiency and speed. Control questions are posed in the context of developmental and regenerative biology, and address long-standing puzzles in areas such as pattern formation, growth regulation, the origins of birth defects, and the avoidance of cancer. Our group is particularly interested in understanding how selection for control imposes order on biological systems, as a result of tradeoffs that arise among competing objectives. These issues are addressed using a variety of traditional approaches: model organisms (mice, flies, fish), genetic manipulation, and genomic analysis. But because control problems are inherently systems-level, the lab exploits the tools of Systems Biology, including mathematical modeling, simulation, large-scale data collection, and live cell imaging. Such work is facilitated through collaborations with mathematicians, computer scientists, physicists and engineers.

Awards and Achievements

NIH-Javits Neuroscience Investigator Award

Elected member of the American Society for Clinical Investigation

Fellow of the American Association for the Advancement of Science

Serves on the Science Board of the Santa Fe Institute

Standing member of the NIH MABS (Modeling and Analysis of Biological Systems) study section

Member of the editorial boards of the PLoS Biology and BMC Biology