Ke Xu

2016 Fellow

Current Institution: University of California, Berkeley


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About Ke Xu's Work

My lab develops next-generation microscopy and spectroscopy tools that offer new functionality, resolution, and sensitivity for biological, chemical, and nanomaterials systems. In particular, we recently developed spectrally resolved super-resolution microscopy to synchronously obtain the fluorescence spectra and positions of millions of single molecules within minutes. Harnessing this capability and further incorporating environment-sensing fluorescent probes, we further demonstrated functional super-resolution microscopy, in which intracellular physicochemical parameters, including local chemical polarity (hydrophobicity), pH, viscosity, and protein activity, are detected with single-molecule sensitivity and nanometer resolution. We thus unveiled nanoscale compositional heterogeneity in live-cell membranes, multipath reaction pathways of single molecules, as well as unexpectedly rich behavior of surface adlayers at the nanoscale.

Awards and Achievements

Sloan Research Fellow

Pew Biomedical Scholar


The Talented 12

Chan-Zuckerberg Biohub Investigator