My group works on developing single-cell microtechnologies to interrogate functional cellular heterogeneity and inter-cellular signaling network in human health and disease. We developed a microchip technology that permits co-detection of 42 immune effector proteins from single cells, representing the highest multiplexing to date for a single-cell protein secretion assay. This microchip called IsoCode has been … Continued
The research currently underway in our group centers around questions in polymer physics and microfluidic/nanofluidic technologies. On the polymer side, we are particularly interested in understanding the dynamics of DNA in nanochannels with applications towards genome mapping. There is also a growing interest in the group on the thermodynamics of block polymers, largely in collaboration … Continued
My research focuses on the use of inertial fluid dynamic effects for the control, separation, and manipulation of particles and fluids in microfluidic devices. These innovations are key components of new commercial instruments that automate purification and analysis of cell populations to diagnose disease and create new cell-based therapies. My recent work leverages the ability … Continued
Correlation of macroscopic material properties and function with molecular structure and dynamics, particularly in heterogeneous macromolecular solids. Synthesis and characterization of self-assembled inorganic-organic and mesoporous materials for catalysis, separations, electrochemical, and opto-electronic applications. Molecular dynamics and structure in hierarchically ordered polymers, liquid crystals, nanocrystals, and biominerals. Development and application of nuclear magnetic resonance spectroscopy methods … Continued
The overall objective of the Burdick Laboratory is to design unique biomaterials for a range of biomedical applications. Our work spans fundamental questions related to polymer synthesis and processing through to clinical applications, particularly in the cardiovascular and musculoskeletal fields. Our group has pioneered the development of polymeric biomaterials – including electrospun fibers, injectable hydrogels, … Continued
My research focuses on the discovery and understanding of fundamental phenomena in the behavior of complex fluid and materials processing flows a using experimental, computational and theoretical tools developed within his research group. Current projects include design of rheological additives, roll-to-roll graphene transfer and directed self-assembly of nanoparticles.
Our lab develops methods of protein engineering by directed evolution, with emphasis on creating enzymes that bring new chemical reactions to life. We use evolution augmented with machine learning to circumvent our profound ignorance of how DNA encodes function in order to create new biological molecules.
Our research revolves around studies of colloidal and interfacial phenomena, ranging from fundamental issues related to colloidal interactions to the application of chemically tailored interfaces in chemical and biological sensors. We have designed and synthesized surfactants that incorporate molecular triggers (redox-active and light-sensitive groups) for reversible control of surfactant-based properties of aqueous systems. We are … Continued
My research group focuses on the development of bioactive and bioresponsive materials that can be used as cell culture systems. Specifically, we design synthetic biomaterials that capture key features of the unique chemistry and physical properties of a cell’s niche—an environment that is not only tissue specific, but can be strikingly heterogeneous and dynamic. Unique … Continued