My lab studies the fundamental principles of brain homeostasis, plasticity, and resilience across multiple scales. Bridging molecular and systems neuroscience, we explore how neural circuits maintain function over an organism’s lifespan, respond to stressors, and compensate for damage and aging. To address these complex questions, we develop transformative technologies spanning imaging, genomics, synthetic biology, and computation that enable unprecedented high-resolution, large-scale measurements of cellular states and activities in intact tissue. By systematically perturbing thousands of genes in parallel within living animals and measuring the resulting phenotypes, we will causally map the molecular circuits underlying brain resilience and vulnerability. Ultimately, we aim to engineer cells and tissues to repair damage, improve resilience, or even rejuvenate function lost with age.