The focus of my lab is the coupling of theoretical, computational, and experimental techniques for the study of structural biology. In particular, we have placed a major emphasis on developing quantitative methods for protein design with the goal of developing a fully systematic design strategy that they call “protein design automation.” Our design approach has been refined and captured in a software program called TRIAD and has been applied to a variety of problems ranging from antibody engineering to the creation of de novo enzymes.

Awards and Achievements

  • Miller Research Fellowship ( 1998)
  • Searle Scholar Award ( 1994)
  • Johnson Foundation Prize for Innovative Research in Structural Biology ( 1997)
  • National Academy of Sciences ( 2004)