Imaging science is a critical enabler of revolutionary scientific advances across disciplines. However, current imaging technologies face prohibitive trade-offs in resolution, penetration depth and experimental complexity. I envision a future where imaging science is unencumbered by these challenges. Here, I introduce “acoustoplasmonic metasurfaces” a new class of nanostructured materials to enable imaging at unprecedented resolution and penetration depth simultaneously, in a miniaturized, on-chip format. Drawing inspiration from super-resolution structured illumination imaging, the proposed acoustoplasmonic metasurfaces will merge the physics of light and sound in previously unexplored ways, opening new avenues to harness wave-matter interactions. The resulting on-chip imaging concept will initiate a bold new branch of nanomaterials research, while enabling a rich palette of societally relevant applications ranging from biomedicine, to industrial materials, to environmental science.