Proteins are molecular machines that are responsible for most processes essential for life. Proteins do not function in isolation and instead are connected through a vast network of dynamic and stable interactions, both with other proteins and with other biomolecules, such as RNA, DNA, or metabolites. Our research seeks to understand how this network of interactions regulates protein function and cellular fate. To improve our capacity to study these interactions, the proposed study will develop a new and broadly applicable approach to globally map the precise sites where interactions occur. We will then apply our approach to understand how and where RNA binding proteins (RBPs) interact with their target RNAs during viral infection. More broadly, our work will build the foundation for a more global understanding of how and to what extent interactions impact protein function.

Awards and Achievements

  • Beckman Young Investigator ( 2019)
  • DARPA Young Faculty Award ( 2019)